Blood Disease Thread

Hi, this thread is for discussing stuff about Blood Diseases!

Feel free to make a reply if you have any info or images about the practical and cosmetic functions of Blood Diseases, such as your own outfit with a Blood Disease or if you have any questions about them.

If you don’t know how to obtain blood diseases yet, then check this quick guide below!

Blood Disease Obtainment

Depending on how many effects you want to have (up to 4 at a time), there are different requirements.

  • For each effect in the blood disease, you will need 10 high quality reagents of that effect. (Such as poison teeth, bloodstone, stormsalt, ect.)
  • You will need 2 Taint Urchin Spine and an additional 2 Taint Urchin Spine if you want to have more than 3 effects.
    These are obtained from Giant Urchins on Poison Biome islands in the Dark Sea, simply use attacks on one until you get the spine.
  • You will need Brewing level 6 if you want to have 2 effects or more.
  • You will need Brewing level 10 if you want to have 3 effects or more.

Once you have the required items, brew them into infused daggers, remember to use a 2nd reagent incase you want 2 or more effects.
If you want 3 or 4 effects, then create two daggers with the effects you want and combine them in the cauldron using the Combine Potions tab.

The order of the effects does matter but only for cosmetic reasons, the last effect is the one that you will get the color of(?)[1]

If you want to cure a Blood Disease, then you will have to find and eat a Moly, a rare herb found in the Far Reaches of the Dark Sea or you can buy one from the marketplace for a decently high price.


  1. This needs confirmation, but from my own experience this seems to be how it works. It might also be purely random? ↩︎

I’ll go first.


This first image is with 3 effects (scorch, bleed, blindness). Blindness effect is completely nullified as it never seemed to apply to anything. Scorch will get nullified if the target is in water.

This second image is with Poison, Bleed, Corroding and is my current one. All debuffs have a much shorter duration when applied from a blood disease (corroding and poison only last about 2-3 ticks) but do seem to apply synergy bonuses although they’re likely reduced by a lot.
3 effects seems to discolor your arm to be skin colored, gives you an aura of steam and turns your hair and eyes white. Alongside causing you to randomly take 50 damage.

The HP loss is about -50% of base max HP at 3-4 (been sent some screenshots of 4 and it doesn’t seem to change at all)
Not every attack will apply blood disease effects, such as Colossal Cleave.

Also 3-4 effects gives you scales on your face, so if you’ve ever wanted to look like an Atlantean or a scalie, now you can!

They gotta buff blood disease or gut greases, fym weapons get a full synergy boost for a tiny amount of power lost while others get 1/4 of a synergy boost in exchange for 30% of their health

Only reason to use blood diseases atm is for the looks, the damage boost is really bad and not that worth it
I do wish that you could get the face scales without discoloring your hair, eyes and arm

the I1 lasts for about 30 seconds, the blindness for a fraction of a second unfortunately.

do we know if they stack alongside greases? i2 off any attack would be amusing, albeit expensive

are damaging effects supposed to last like a fraction of a second? ive applied a scorch disease on myself but i just never see the effect in action :broken_heart:

half my hp??? :fearful:

he should just reduce the % of health you lose tbh.

yeah 30% base health for an effect at 1/4th the synergy effect? with even 1 single blood disease all being locked at T1?

What the hell even is a blood disease

With a little bit of experimenting, I’ve learned that blinding BD is useless, and Burning BD + powder fist doesn’t apply petrify.

does the amount of effects affect the health penalty, and can you stack one single effect multiple times?

Yeah, 1 effect is 30%, and 4 is 50% of your base HP. It seems to be incremental so I’ll be honest, unless you use 2, losing 30% HP isn’t really worth it.

well then what if I used 3?

The effects aren’t even really worth in the first place to be honest, losing 40ish% of your HP in exchange for 25 extra damage isn’t worth

well then what if I want to be green, huh?

Not even +25, that synergy would have to normally give +100 damage, which alone requires an enormous amount power

anything that isnt a damaging status or healing for blood disease SUCKS!!! i hope it eventually gets buffed later on or the health reduction is less severe because it otherwise isnt worth running at any stage unless you want cosmetic changes

the little thing i do like about blood disease is the more you give yourself, the icon for it on your info profile begins to list it as arcane corruption, like this is what it looks like w/ 4 diseases:

If u using Electro crystals, you get “Electro” or “Paralyzed” status effect?

on another note I yes I am selling 1 moly